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Laboratory of Cell & Molecular Biology
Molecular Biology Laboratory
Lee J, Cho H* and Kwon I* (2022) Phase separation of low-complexity domains in cellular function and disease. Exp. Mol. Med. 54:1-11 (Review article, *Co-corresponding authors)
An X, Lee J, Kim GH, Kim H, Pyo H, Kwon I* and Cho H* (2022) Modulation of IKs channel–PIP2 interaction by PRMT1 plays a critical role in the control of cardiac repolarization. J. Cell. Physiol. 1-11. https://doi.org/10.1002/jcp.307 75 (*Co-corresponding authors)
Jo Y*, Lee J*, Lee S*, Kwon I** and Cho H** (2022) Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS. Proc. Natl. Acad. Sci. 119 (11) e2113813119. (*Co-first authors; **Co-corresponding authors)
Kim GH and Kwon I (2021) Distinct roles of hnRNPH1 low-complexity domains in splicing and transcription. Proc. Natl. Acad. Sci. 118 (50) e2109668118.
Kim E and Kwon I (2021) Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin. Biochem. J. 478 (4):799-810.
Lee S, Vuong TA, So H, Kim H, Kim YB, Kang J, Kwon I*, and Cho H* (2020) PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors. Exp. Mol. Med. 52(4):604-614. (*Co-corresponding authors)
Lee S, Vuong TA, Wen X, Jeong H, So H, Kwon I, Kang J, and Cho H (2019) Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells. Exp. Mol. Med. 51(10):119.
Kim JG, Leem Y, Kwon I, Kang J, Bae YM, and Cho H (2018) Estrogen modulates serotonin effects on vasoconstriction through Src inhibition. Exp. Mol. Med. 50:167.
Lee J, Park E, Kim GH, Kwon I*, Kim K* (2018) A splice variant of human Bmal1 acts as a negative regulator of the molecular circadian clock. Exp. Mol. Med. 50:159. (*Co-corresponding authors)
Lin Y, Mori E, Kato M, Xiang S, Wu L, Kwon I*, and McKnight SL* (2016) Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target LC domain polymers. Cell. 167:789-802. (*Co-corresponding authors)
Kwon I, Xiang S, Kato M, Wu L, Theodoropoulos P, Wang T, Kim J, Yun J, Xie Y, and McKnight SL (2014) Poly-dipeptides encoded by the C9ORF72 repeats bind nucleoli, impede RNA biogenesis, and kill cells. Science. 345:1139-45.
Kwon I*, Kato M*, Xiang S, Wu L, Theodoropoulos P, Mirzaei H, Han T, Xie S, Corden JL, and McKnight SL (2013) Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains. Cell. 155:1049-60. (*Co-first authors)
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